Quercetin and histamine effects of the content of superoxide anion and ATP in the blood plasma of rats

Background. Histamine is one of the versatile biogenic amines with multiple roles in immune response and allergic disorders. ATP can act as ligands body. In plasma, a potent vasodilator that stimulates formation NO prostaglandins and, very importantly, offset local sympathetic vasoconstriction. Adenosine triphosphate released into plasma from erythrocytes endothelial cells, concentration increases both feed artery vein draining contracting skeletal muscle. Taking this account, it important to study effect histamine combination quercetin, which inhibits release cellular depots, on content superoxide anion blood plasma. Materials Methods. Nonlinear white male rats were used for experimental studies. Quercetin solutions added whole final 0.1; 0.3; 0.5; 1; 3; 5 mM. other experiments, solution was 0.01; 10 μM. series (0.01 μM) quercetin (0.1; mM) various possible combinations. Blood each group. The saline control. adenosine measured selected samples. Results Discussion. Histamine, well their combined action lead intensification generation rats. known be an antioxidant, but some our studies have shown opposite effect. causes increase same only at concentrations 0.1 µM. Likewise, administration increased content. results ANOVA test prove cells Their strengthens releasing studied products. Conclusion. Quercetin, cause